Expert Rev Clin Pharmacol. Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency. View abstract. J Neurol Sci 2000;176:124-7. Among the five cases, ashwagandha dosing ranged from 450 to 1,350 milligrams daily. Last updated on Feb 3, 2023. This information may not fit your specific health circumstances. J Evid Based Complementary Altern Med. J Atten Disord 2010;14:281-91. Serotonin syndrome can even result in death. Herb-drug interactions. ashwaganda: Dosing, contraindications, side effects, and pill pictures - epocrates online Drug Lookup: Browse: Drugs Alt Meds Select a medication above to begin. Ashwagandha may be toxic to the liver (hepatotoxic). Akhgarjand C, Asoudeh F, Bagheri A, et al. 2019;11(9):e5797. Cureus. View abstract. Answered by Dr. Brian Staiger, PharmD It's worth noting that a drawback of both these studies is that they were performed on small sample sizes. These include drugs like thyroid desiccated, levothyroxine, or liotrix. The best time to take ashwagandha is at the time that works best for you. Front Pharmacol 2022;13:901710. 2013;45(4):417-8. Sud Khyati S, Thaker B. 2013;2013:571420. View abstract. Kaur, K., Rani, G., Widodo, N., Nagpal, A., Taira, K., Kaul, S. C., and Wadhwa, R. Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Now, most studies suggest that ashwagandha doesn't have significant blood pressure lowering effects, so the interaction here is thought to be relatively mild. Ashwagandha may be able to help with insomnia. Participants of this study received either a placebo or 300 milligrams of ashwagandha twice per day for eight weeks. This information does not contain all possible interactions or adverse effects. 1988;26(11):877-882. hydrochlorothiazide, spironolactone, chlorthalidone). Go to the ER right away. View abstract. Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. This is according to a recent review of case studies of liver damage caused by ashwagandha. 2012;10(1):48-49. Ashwagandha can react with certain medications and supplements you may already take, and result in adverse effects. No, Ashwagandha does not possess any qualities that cause it to be habit forming, and the risk of forming an addiction to Ashwagandha is little to none. Does Synthroid interact with supplements that may help with arthritis, such as ashwagandha, collagen, or turmeric? This herb used in alternative medicine may help reduce stress. 2018 Mar;24(3):243-248. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! View abstract. Ashwagandha may have additive effects to certain drugs that are used for diabetes, high blood pressure, and low thyroid hormone, to name a few. Anbalagan, K. and Sadique, J. Ashwagandha may have additive effects to certain drugs that are used for diabetes, high blood pressure, and low thyroid hormone, to name a few. View abstract. They should also be kept from direct sunlight and stored in their original bottle or container. View abstract. The effect of total alkaloids on the smooth muscles. Take extra care if you are taking drugs to help with your thyroid. What to Look for When Choosing Ashwagandha Supplements, Uses of Lavender: Everything You Need to Know, I Tried Taking Ashwagandha and It Gave Me Crazy Vivid Dreams, Natural withanolides in the treatment of chronic diseases, Pharmacological evaluation of ashwagandha highlighting its healthcare claims, safety, and toxicity aspects, Potential clinical applications of Ashwagandha (, Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study, An investigation into the stress-relieving and pharmacological actions of an ashwagandha (, An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (, Efficacy and safety of Ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study, A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (, Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers, Ashwagandha-induced liver injury: a case series from Iceland and the US Drug-Induced Liver Injury Network, DNA damage by withanone as a potential cause of liver toxicity observed for herbal products of, Effects of L-Theanine administration on stress-related symptoms and cognitive functions in healthy adults: a randomized controlled trial, Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency, Vitamin E, turmeric and saffron in treatment of Alzheimer's disease, Tart cherry juice in athletes: a literature review and commentary, Dietary supplements: what you need to know. Ashwagandha can also interact with some medications and affect how they work. Kuppurajan K, Rajagopalan SS, Sitoraman R, and et al. Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. Does Ashwagandha Interact With Any Medications? However, tyramine-rich foods like cheeses, beer and other fermented products are dangerous for people taking MAOIs. Agarwal R, Diwanay S, Patki P, Patwardhan B. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. Bhat, J., Damle, A., Vaishnav, P. P., Albers, R., Joshi, M., and Banerjee, G. In vivo enhancement of natural killer cell activity through tea fortified with Ayurvedic herbs. doi:10.7759/cureus.6466, Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: a randomized, double-blind, placebo-controlled study. View abstract. Other essential vitamins and minerals may also be helpful in treating depression. View abstract. Upadhaya L and et al. Therefore, it should be used cautiously with drugs used to treat diabetes, including: Just like with potential interactions between ashwagandha and diabetes drugs, there may be a potential issue with drugs used to treat high blood pressure as studies show ashwagandha mayhave blood-pressure-lowering effects. Always check with your doctor before you use a natural product. These medications work in the brain by indirectly enhancing the action of a chemical in the brain called gamma-aminobutyric acid (GABA) a neurotransmitter that has a calming effect which helps lower anxiety levels. Animal research and one case study indicate that the herb might increase serum concentration of thyroid hormones, according to Ray Sahelian, a medical doctor who specializes in natural supplements. Liver damage. View abstract. PLoS One 2009;4:e6628. However, some adverse effects are generally associated with ashwagandha. For example, it may increase the sedative effect of medications that treat anxiety and insomnia. If you have blood sugar problems, keep hard candies, glucose tablets, liquid glucose, or juice on hand for low blood sugar. Sometimes, these supplements are stand-alone products or multivitamins; in other cases, they are mixed in with healthy food products, like spirulina, chlorella or herbal products. Ashwagandha may interact with various medications. Evid Based Complement Alternat Med. The combination could result in excess thyroid hormone in the body, which has many negative effects. Certain ingredients can influence the effectiveness of your antidepressants and how they affect your health. View abstract. . Sedatives: Since ashwagandha can both energize and induce restorative sleep, it might negate or amplify the effect of other sedative drugs, especially the benzodiazepines. Hydroxyzine has moderate interactions with at least 207 different drugs. Ashwagandha may be used for anxiety due to its perceived anti-inflammatory and antioxidant properties. View abstract. Who Shouldn't Take Ashwagandha? Lu, L., Liu, Y., Zhu, W., Shi, J., Liu, Y., Ling, W., and Kosten, T. R. Traditional medicine in the treatment of drug addiction. Drugs that cause sleepiness and drowsiness are called sedatives. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. View abstract. Ashwagandha may interact with certain drugs by enhancing or negating their actions. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. A total of 203 drugs are known to interact with levothyroxine . 2014;20(12):901-908. doi:10.1089/acm.2014.0177, Remenapp A, Coyle K, Orange T, et al. The length of use of ashwagandha ranged from 14 to 110 days, and doses ranged from 450 milligrams to 1,350 milligrams per day. In rare cases, ashwagandha may cause liver damage. Ashwagandha appears to stimulate your endocrine system . One study, published in Phytotherapy Research, reported that ashwagandha supplementation reduced blood sugar and A1c levels, although this was a relatively small study. Ireland PJ, Hardy T, Burt AD, Donnelly MC. This dosing has also been associated with improvements in memory. 2021;6(1):20. doi:10.3390/jfmk6010020, Langade D, Kanchi S, Salve J, Debnath K, Ambegaokar D. Efficacy and safety of ashwagandha (Withania somnifera) root extract in insomnia and anxiety: a double-blind, randomized, placebo-controlled study. Curr Res Toxicol. View abstract. Taking ashwagandha along with these medications might decrease the effects of these medications. Association of l-DOPA with recovery following Ayurveda medication in Parkinson's Disease. According to a December 2012 study in the Journal of Medicine and Life, SSRIs are primarily the recommended treatment for depression. I am wondering if it is okay to take with my prescriptions. Available for Android and iOS devices. Cancer Lett 2000;148:9-17. Gopal S, Ajgaonkar A, Kanchi P, et al. Its effects on arterial blood pressure in anaesthetized dogs. It is just a general precaution that ashwagandha may decrease blood sugar. Is Fish Oil Dangerous With Antidepressants? Take extra care if you are taking iron supplements. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat. Use birth control you can trust while taking this product. Levothyroxine is used to treat the following conditions: Hashimoto's disease. View abstract. View abstract. Significant improvements were seen in all sleep parameters for those who took ashwagandha (300 milligrams twice daily). Often, herbs and supplements come with a risk of side effects. 1992;30(3):169-172. There is little evidence for its use as an "adaptogen." Ashwagandha contains chemicals that might help calm the brain, reduce swelling, lower blood pressure, and alter the immune system. Davis, L. and Kuttan, G. Effect of Withania somnifera on DMBA induced carcinogenesis. View abstract. Never start, stop or otherwise change your therapy before speaking with your provider. J Funct Morphol Kinesiol. It may cause you to become sleepy or drowsy. View abstract. Herbs like Ashwagandha are known to interact with SSRI and other medicines. Supplements that are similar to ashwagandha include: It's typically best to take just one supplement or herb at a time for a medical condition. It may also interact with medications for these conditions. J Ethnopharmacol. In rare cases, the use of ashwagandha may lead to liver damage. Medicine (Baltimore). Most reported drug interactions are based on the potential additive effectswhen combined with certain drugs (e.g. Singh, R. H., Narsimhamurthy, K., and Singh, G. Neuronutrient impact of Ayurvedic Rasayana therapy in brain aging. This means not enough is known about either the safety or effectiveness of taking daily ashwagandha for an extended period of time. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. Lousewort - Amiloride, Hydrochlorothiazide, Cassia Cinnamon - Aspirin, Butalbital, Caffeine, Abuta - Bismuth Subcarbonate, Calcium Carbonate, Opium, English Adder's Tongue - Inotuzumab Ozogamicin, Patricia Kane (pk) Protocol - Indomethacin, Pulsed Electromagnetic Field (pemf) Therapy - Cabozantinib. Chengappa KN, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R. Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder. 2021;16(9):e0257843. An eight-week safety study found that taking 300 milligrams daily of ashwagandha was safe for both males and females. Certain antidepressants may not be compatible with herbs or other natural ingredients in these products. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider's examination and assessment of a patients specific and unique circumstances. How to use To use ashwagandha products safely, people must always follow the dosage advice given by the manufacturer. View abstract. https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms. This is one of the more common food-drug reactions. Curr Sports Med Rep. 2017;16(4):230-239. doi:10.1249/JSR.0000000000000385. National Center for Complementary and Integrative Health. Be sure to tell your doctor that you take this product if you are scheduled for surgery or tests. Talk with a healthcare provider about which herb or supplement may be best for you. This includes people who have had a transplant, are on chemo, or have an autoimmune disease. lisinopril, captopril, benazepril, quinapril), ARBs (e.g. Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. 2005 - 2023 WebMD LLC, an Internet Brands company. Ashwaganda is used to treat Herbal Supplementation. Ultimately, the supplements and foods you can . Baker C, Kirby JB, O'Connor J, Lindsay KG, Hutchins A, Harris M. The perceived impact of ashwagandha on stress, sleep quality, energy, and mental clarity for college students: qualitative analysis of a double-blind randomized control trial. Supplements That Are Similar to Ashwagandha. Skinmed. It should not be confused with Physalis alkekengi, which is also referred to as winter cherry. Always talk with a healthcare provider before starting any new supplement regimen. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Malhotra, C. L., Mehta, V. L., Prasad, K., and Das, P. K. Studies on Withania ashwagandha, Kaul. Acta Oncol. It is commonly used for stress. Ashwagandha has mild interactions with at least 29 different drugs. Ashwagandha is not naturally found in foods, which means the only way to get it is through supplements. View abstract. Be sure to let your doctor know if you plan on adding ashwagandha to your medication list so you can be appropriately monitored. View abstract. Notably, ashwagandha doses typically do not exceed 1,000 milligrams per day for up to 12 weeks. Take extra care driving and doing tasks that you need to be alert for while taking this product. losartan, valsartan, telmisartan), Beta-Blockers (e.g. PLoS.One. View abstract. After 30 days, those who took either dose of ashwagandha self-reported positive effects on their anxiety. Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Bhattacharya, S. K. and Muruganandam, A. V. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. 1998;60(2):173-178. They also are not very good drugs, because they have multiple potentially . Does Ashwagandha Interact With Any Medications? Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Immunopharmacol.Immunotoxicol. Just be sure to choose a supplement from a reputable manufacturer and follow the . Xanax is in the drug class benzodiazepines. Learn about the uses and potential benefits of Ashwagandha including dosage guidelines, side effects, interactions and safety/efficacy ratings. This product may interfere with some lab tests. If you take thyroid medicine, consult your doctor before using ashwagandha. We can, however, make some educated guesses on drug interactions based on ashwagandha works, and the effects it is known to have. Herbal supplements can strongly affect the body. Influence of an Indian medicine (Ashwagandha) on acute-phase reactants in inflammation. The April 2008 issue of "Therapeutic Drug Monitoring" notes that some herbal products interfere with methodology used to measure drug levels in a patient's bloodstream. 2019;11(12):e6466. You can also use ashwagandha as an herbal tea. 2022;15(9):1067-1080. doi:10.1080/17512433.2022.2121699, Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. Ashwagandha dosing may vary by brand or reason for use. Dongre S, Langade D, Bhattacharyya S. Efficacy and safety of ashwagandha (withania somnifera) root extract in improving sexual function in women: a pilot study. Neurol India 2009;57:166-71. View abstract. A total of 525 drugs are known to interact with Xanax. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. People using ashwagandha for physical performance may need to take higher doses of up to 1,250 milligrams daily to see benefits. View abstract. Ahumada F, Aspee F, Wikman G, and et al. . I was told that I had an allergic reaction to penicillin when I was a child. The news available in this regard in . Effect of Indian Ayurvedic medicine Ashwagandha on measurement of serum digoxin and 11 commonly monitored drugs using immunoassays: study of protein binding and interaction with Digibind. Varying levels of research have looked at the potential benefits of ashwagandha. Ashwagandha can increase the activity of the immune system. View abstract. 1965;9(1):9-15. The Journal of Psychiatry study reported that omega-3 fats and vitamin D are the two essential nutrients that are most likely to help reduce depression symptoms.
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